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KB02-COOH

KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF (HY-129610).

Product Specifications

CAS Number

2375196-30-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kb02-cooh.html

Purity

98.88

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=CC2=C(N(C(CCl)=O)CCC2)C=C1

Molecular Formula

C13H14ClNO4

Molecular Weight

283.71

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15 (7) :737-746.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

Frequently Asked Questions

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