KB02-COOH
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 (HY-129917) and KB02-SLF (HY-129610) [1].
Product Specifications
CAS Number
[2375196-30-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kb02-cooh.html
Purity
98.88
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(O)COC1=CC2=C(N(C(CCl)=O)CCC2)C=C1
Molecular Formula
C13H14ClNO4
Molecular Weight
283.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15 (7) :737-746.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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