4-Acetylaminoantipyrine

4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171) . 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) [1]. 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation[3].

Product Specifications

CAS Number

[83-15-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; PGE synthase; SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-acetylaminoantipyrine.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(NC(C)=O)C(N(N1C)C2=CC=CC=C2)=O

Molecular Formula

C13H15N3O2

Molecular Weight

245.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Berno CR, et al. Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. |[2]Teng Y, et al. Insights into potentially toxic effects of 4-aminoantipyrine on the antioxidant enzyme copper-zinc superoxide dismutase. J Hazard Mater. 2013 Nov 15;262:318-24.|[3]Teng Y, et al. The interaction between 4-aminoantipyrine and bovine serum albumin: multiple spectroscopic and molecular docking investigations. J Hazard Mater. 2011 Jun