3-sucCA

3-sucCA is an orally available bacterial bile acid that exerts anti-MASH effects by promoting the growth of Akkermansia muciniphila. By remodeling the intestinal microbiota and promoting the growth of Akkermansia, 3-sucCA can improve intestinal barrier damage and reduce chronic low-level inflammation, thereby alleviating the progression of metabolic dysfunction-associated steatohepatitis (MASH) . 3-sucCA accelerates the synthesis of cell wall peptidoglycan and has in vivo efficacy in the mouse MAFL-MASH model. 3-sucCA levels are low in the MAFLD model and are mainly used in the study of MASH[1][2].

Product Specifications

CAS Number

[94159-47-4]

Product Name Alternative

3-Succinylated cholic acid

UNSPSC

12352211

Target

Bacterial; Endogenous Metabolite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/3-succa.html

Purity

99.75

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)OC(CCC(O)=O)=O)([H])C1)C)O)C

Molecular Formula

C28H44O8

Molecular Weight

508.64

References & Citations

[1]Nie Q, et al. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell. 2024 May 23;187 (11) :2717-2734.e33.|[2]Chang S, et al. Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis. iScience. 2025 Jan 2;28 (2) :111731.