GSK3β-peptide

GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of GSK3-β and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs[1].

Product Specifications

CAS Number

[496856-73-6]

UNSPSC

12352209

Target

Akt; GSK-3

Type

Peptides

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk3β-peptide.html

Purity

99.69

Smiles

OC(CC[C@@H](C(O)=O)NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@@H](NC(CN)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C47H76N16O16

Molecular Weight

1121.20

References & Citations

[1]Kayser, et al. "Modifications of the GSK3β substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics." Bioorganic & medicinal chemistry letters 17.7 (2007) : 2068-2073.