GSK2334470
GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.
Product Specifications
CAS Number
[1227911-45-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2334470.html
Purity
99.79
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C([C@@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[C@H](C)CC1)NC5CCCCC5
Molecular Formula
C25H34N8O
Molecular Weight
462.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Najafov A, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J.?2011 Jan 15;433 (2) :357-69.|[2]Qi L, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int.?2015 Sep 29;15:91.|[3]Scortegagna M, et al. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf (V600E) ::Pten (-/-) melanoma. Oncogene. 2014 Aug 21;33 (34) :4330-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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