GSK2334470

GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM.

Product Specifications

CAS Number

[1227911-45-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PDK-1

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK2334470.html

Purity

99.79

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C([C@@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[C@H](C)CC1)NC5CCCCC5

Molecular Formula

C25H34N8O

Molecular Weight

462.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Najafov A, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J.?2011 Jan 15;433 (2) :357-69.|[2]Qi L, et al. PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells. Cancer Cell Int.?2015 Sep 29;15:91.|[3]Scortegagna M, et al. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf (V600E) ::Pten (-/-) melanoma. Oncogene. 2014 Aug 21;33 (34) :4330-9.