IGF1R Antibody (Phospho-Tyr1161)

Product Specifications

CAS Number

9007-83-4

Gene Name

Insulin-like growth factor 1 receptor

Gene Aliases

IGFR, CD221, IGFIR, JTK13

Gene ID

3480; 16001; 16337; 25718

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human IGF-IR (phospho Tyr1161)

Target

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Clonality

Polyclonal

Type

Polyclonal Antibody

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit anti-serum by affinity-chromatograhy.

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Format

Liquid// PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Reconstitution

Store at -20° C for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles.

Fragment

IgG

Specificity

Phospho-IGF-IR-Tyr1161 polyclonal antibody (Insulin-like growth factor 1 receptor and Insulin receptor) binds to endogenous Insulin-like growth factor 1 receptor and Insulin receptor at the amino acid region 1100-1180 only when phosphorylated at Tyr1