Amyloid Oligomers (A11) Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Eukaryotic translation initiation factor 3 subunit p42
Gene Aliases
Amyloid Oligomer alpha beta, A11, Amyloid Oligomer AlphaBeta, APP
Gene ID
8666
Reactivity
Human, Mouse, Rat, Eukaryote
Immunogen
Synthetic molecular mimic of soluble oligomers
Target
Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres. These include the amyloid-beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinson’s disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease.
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB, IHC, ICC, IF, IP, ELISA
Purification
Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
Varies by lot. See vial for concentration.
Format
Liquid.// PBS, 50% glycerol, 0.09% sodium azide
Buffer
PBS, 50% glycerol, 0.09% sodium azide
Reconstitution
Store at -20° C for 1 year.
Notes
Formerly GWB-DM1A11
Specificity
Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
NCBI Gene Symbol
Amyloid
Host or Source
Rabbit
Gene Name URL
Amyloid
Nucleotide Accession Number
NM_000484.2
Frequently Asked Questions
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