NALCN Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Sodium leak channel, non-selective
Gene Aliases
VGCNL1, CanIon, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, A530023G15Rik, bA430M15.1, FLJ23913, FLJ44659, FLJ44764, Four repeat voltage gated ion channel, MGC74524, Putative 4 repeat voltage gated ion channel, Sodium leak channel non-selective protein
Gene ID
266760
Accession Number
NP_705894.1
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
Target
NALCN (sodium leak channel non-selective protein), also known as Canlon or VGCNL1 (voltage gated channel-like protein 1) is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCNis highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exist due to alternative splicing events.
Clonality
Monoclonal
Clone
S187-7
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
WB, ICC, IF
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Format
Liquid// PBS (pH 7.4) with 50% glycerol and 0.09% sodium azide
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Reconstitution
Store at -20C. Shipping with Blue Ice or 4C.
Molecular Weight
~200 kDa
Fragment
IgG1
Specificity
Detects ~200kDa.
NCBI Gene Symbol
NALCN
Host or Source
Mouse
Gene Name URL
NALCN
Curated Selection
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