KCC2 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Solute carrier family 12 (potassium-chloride transporter), member 5
Gene Aliases
Potassium Chloride Cotransporter, Potassium chloride transporter 5, SLC12A5, hKCC2, S12A5, Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, Furosemide-sensitive K-Cl cotransporter, K-Cl cotransporter 2, rKCC2, Neuronal K-Cl cotransporter, KIAA1176, Electroneutral potassium chloride cotransporter 2, Erythroid K Cl cotransporter 2, Furosemide sensitive K Cl cotransporter, K-Cl cotransporter 2, KCC 2, Neuronal K Cl cotransporter, Solute carrier family 12 (potassium chloride transporter) member 5, Solute carrier family 12 member 5
Gene ID
171373
Accession Number
NP_599190
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 932-1043 corresponding to rat KCC2
Target
KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
Clonality
Monoclonal
Clone
S1-12
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
WB, IHC, ICC, IF, IP
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:300), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Format
Liquid.// PBS (pH 7.4) with 50% glycerol and 0.09% sodium azide.
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Reconstitution
Store at -20C. Shipping with Blue Ice or 4C.
Molecular Weight
140 kDa
Fragment
IgG2a
Specificity
Detects ~140kDa.
NCBI Gene Symbol
KCC2
Host or Source
Mouse
Gene Name URL
KCC2
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