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Human CD16 Antibody : Biotin

Product Specifications

CAS Number

9007-83-4

Gene Name

Low affinity immunoglobulin gamma Fc region receptor III-A

Gene Aliases

CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA

Gene ID

2214

Accession Number

NP_000560.6

Reactivity

Human

Immunogen

Mononuclear cells from a prolymphocytic B-leukemia

Target

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Clonality

Monoclonal

Clone

GRM1

Conjugation

Biotin

Type

Monoclonal Antibody

Applications

FC, IHC-F, IP, WB

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

Lot specific

Dilution

6 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells6666

Reconstitution

Store at 2-8C

Fragment

IgG2a

Specificity

CD16

NCBI Gene Symbol

FCGR3A

Host or Source

Mouse

Protein Name

Low affinity immunoglobulin gamma Fc region receptor III-A

Gene Name URL

FCGR3A

Nucleotide Accession Number

NM_000569.7

Frequently Asked Questions

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