IGF1R Antibody
Product Specifications
CAS Number
9007-83-4
Gene Aliases
IGFR, CD221, IGFIR, JTK13
Gene ID
3480
Accession Number
NP_000866.1
Reactivity
Human
Immunogen
Purified human placental IGF-I receptor.
Target
CD221 is a receptor tyrosine kinase. CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.
Clonality
Monoclonal
Clone
1H7
Conjugation
LE: Low Endotoxin
Type
Monoclonal Antibody
Applications
Flow cytometry|Functional assay|Immunohistochemistry-Paraffin|Western blot
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human
Format
Liquid. Phosphate buffered saline
Reconstitution
-20°C
Molecular Weight
~155 kDa
Notes
Formerly GWB-F08AE0
Fragment
IgG1
Specificity
CD221. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signaling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221.
Protein Length
1367
NCBI Gene Symbol
IGF1R
Host or Source
Mouse
Protein Name
Insulin-like growth factor 1 receptor
Gene Name URL
IGF1R
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