NaV1.2/1.6 channel blocker-1
NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1].
Product Specifications
CAS Number
1199944-04-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-2-1-6-channel-blocker-1.html
Purity
98.89
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
S=C1OC2=CC=CC=C2C3=NC(C)=C(CCC)N13
Molecular Formula
C14H14N2OS
Molecular Weight
258.34
Precautions
H302, H315, H319
References & Citations
[1]Rivara M, et, al. Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers. Letters in Drug Design & Discovery, 2014, 11, 90-97.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.2; Nav1.6
Available Sizes
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