NaV1.2/1.6 channel blocker-1

NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1].

Product Specifications

CAS Number

[1199944-04-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nav1-2-1-6-channel-blocker-1.html

Purity

98.89

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

S=C1OC2=CC=CC=C2C3=NC(C)=C(CCC)N13

Molecular Formula

C14H14N2OS

Molecular Weight

258.34

Precautions

H302, H315, H319

References & Citations

[1]Rivara M, et, al. Biological Evaluation of Imidazobenzoxazines, Imidazobenzoxazin-5-ones and Imidazobenzoxazin-5-thiones as Sodium Channel Blockers. Letters in Drug Design & Discovery, 2014, 11, 90-97.