Sptan1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Spectrin alpha chain, non-erythrocytic 1
Gene Aliases
A2a, IPF, Spna2
Gene ID
64159
Accession Number
NP_741984.2
Reactivity
Human, Rat, Cow
Immunogen
Recombinant construct containing the seventh, eighth and ninth repeats of human alpha II spectrin expressed in and purified from E. Coli.
Target
The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (alpha 1 and alpha 2) and five beta genes (beta 1- beta 5) . Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001) . Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004) .
Clonality
Monoclonal
Clone
3D7
Type
Monoclonal Antibody
Applications
WB, IF
Purification
Affinity purified from tissue culture supernatant.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Homology
Cow; Human; Rat
Format
Liquid. 100 ul in PBS + 10 mM sodium azide
Reconstitution
Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Molecular Weight
~240kDa
Fragment
1
Specificity
Specific for the ~240 k alpha II spectrin protein.
NCBI Gene Symbol
SPTAN1
Host or Source
Mouse
Protein Name
Spectrin alpha chain, non-erythrocytic 1
Gene Name URL
Sptan1
Nucleotide Accession Number
NM_171983.2
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