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Anti-Syntaxin 1A

Product Specifications

CAS Number

9007-83-4

Gene Aliases

STX1, HPC-1, P35-1, SYN1A

Gene ID

6804

Accession Number

NP_001159375.1

Reactivity

Human, Rat, Pig

Immunogen

Synaptic immunoprecipitate (crude) from human brain.

Target

Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007) . Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010) .

Clonality

Monoclonal

Clone

SP8

Type

Monoclonal Antibody

Applications

WB, IHC

Purification

Protein G purified culture supernatant.

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Homology

Human; Pig; Rat

Format

Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Reconstitution

Store at -20C; stable for at least one year.

Molecular Weight

~36kDa

Fragment

1

Specificity

The antibody is specific for the ~ 36 kDa syntaxin protein in Western blots of rat brain lysate. The antibody has also been used for immunohistochemistry on formalin fixed, vibratome sections. Does not work on paraffin sections.

NCBI Gene Symbol

STX1A

Host or Source

Mouse

Protein Name

Syntaxin-1A

Gene Name URL

STX1A

Frequently Asked Questions

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