HOPX Antibody - N-terminal
Product Specifications
CAS Number
9007-83-4
Gene Name
HOP homeobox
Gene Aliases
CAMEO; HOD; homeodomain-only protein; HOP; LAGY; lung cancer-associated Y protein; NECC1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; OB1; odd homeobox protein 1; SMAP31; TOTO.
Gene ID
84525
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_001138932
Reactivity
Bovine|Chicken|Human|Mouse|Porcine|Rat
Immunogen
HOPX antibody was raised against a 16 amino acid peptide near the amino terminus of human HOPX. The immunogen is located within the first 50 amino acids of HOPX.
Target
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity) . May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. HOPX antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
Predicted: 12 kDa Observed: 18 kDa
Fragment
IgG
NCBI Gene Symbol
HOPX
Host or Source
Rabbit
Protein Name
Homeodomain-only protein|homeodomain-only protein isoform c [Homo sapiens]
Gene Name URL
HOPX
Nucleotide Accession Number
NM_001145459.1
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