PPM1D Antibody - C-terminal
Product Specifications
CAS Number
9007-83-4
Gene Name
Protein phosphatase, Mg2+/Mn2+ dependent 1D
Gene Aliases
IDDGIP; JDVS; p53-induced protein phosphatase 1; PP2C-DELTA; protein phosphatase 1D; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; WIP1.
Gene ID
8493
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_003611
Reactivity
Human|Mouse|Rat
Immunogen
PPM1D antibody was raised against an 18 amino acid peptide near the carboxy terminus of human PPM1D. The immunogen is located within the last 50 amino acids of PPM1D.
Target
Involved in the negative regulation of p53 expression (PubMed:23242139) . Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512) . Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629) . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. PPM1D antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
Predicted: 67 kDa Observed: 68 kDa
Fragment
IgG
NCBI Gene Symbol
PPM1D
Host or Source
Rabbit
Protein Name
Protein phosphatase 1D|protein phosphatase 1D [Homo sapiens]
Gene Name URL
PPM1D
Nucleotide Accession Number
NM_003620.3
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