PTPN5 Antibody - N-terminal
Product Specifications
CAS Number
9007-83-4
Gene Name
Protein tyrosine phosphatase non-receptor type 5
Gene Aliases
Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) ; protein-tyrosine phosphatase striatum-enriched; PTPSTEP; STEP; STEP61; striatal-enriched protein tyrosine phosphatase; striatum-enriched protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 5.
Gene ID
84867
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_008837
Reactivity
Human|Mouse
Immunogen
PTPN5 antibody was raised against an 18 amino acid peptide near the amino terminus of human PTPN5. The immunogen is located within amino acids 180 - 230 of PTPN5.
Target
The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1) . It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2) . NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3) . Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5) . PTPN5 may play a role in Alzheimer's disease (1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. PTPN5 antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
Predicted: 62 kDa Observed: 60 kDa
Fragment
IgG
NCBI Gene Symbol
PTPN5
Host or Source
Rabbit
Protein Name
PTPN5 protein|tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens]
Gene Name URL
PTPN5
Nucleotide Accession Number
NM_001039970.1
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