PPARGC1A Antibody - C-terminal
Product Specifications
CAS Number
9007-83-4
Gene Name
PPARG coactivator 1 alpha
Gene Aliases
LEM6; Ligand effect modulator 6; ligand effect modulator-6; L-PGC-1alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC-1 (alpha) ; PGC1A; PGC-1alpha; PGC-1-alpha; PGC-1v; PPAR gamma coactivator variant form; PPARgamma coactivator 1alpha; PPARGC1; PPARGC-1-alpha.
Gene ID
10891
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_037393
Reactivity
Bovine|Human|Mouse|Porcine|Rat
Immunogen
PPARGC1A antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PPARGC1A. The immunogen is located within the last 50 amino acids of PPARGC1A.
Target
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
2°C to 8°C
Molecular Weight
Predicted: 90 kDa Observed: 88 kDa
Fragment
IgG
NCBI Gene Symbol
PPARGC1A
Host or Source
Rabbit
Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha|peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 2 [Homo sapiens]
Gene Name URL
PPARGC1A
Nucleotide Accession Number
NM_013261.3
Curated Selection
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