KANK1 Antibody - N-terminal
Product Specifications
CAS Number
9007-83-4
Gene Name
KN motif and ankyrin repeat domains 1
Gene Aliases
ANKRD15; ankyrin repeat domain-containing protein 15; CPSQ2; KANK; kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1.
Gene ID
23189
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_055973
Reactivity
Human|Mouse
Immunogen
KANK1 antibody was raised against a 19 amino acid peptide near the amino terminus of human KANK1 . The immunogen is located within the first 50 amino acids of KANK1.
Target
Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. KANK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
2°C to 8°C
Molecular Weight
Predicted: 149 kDa Observed: 150 kDa
Fragment
IgG
NCBI Gene Symbol
KANK1
Host or Source
Rabbit
Protein Name
KN motif and ankyrin repeat domain-containing protein 1|KN motif and ankyrin repeat domain-containing protein 1 isoform L [Homo sapiens]
Gene Name URL
KANK1
Nucleotide Accession Number
NM_001256876.1
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