What is the catalog number for TANK Antibody?

The catalog number for TANK Antibody is OAPB00434-100UG.

What sizes are available for TANK Antibody?

TANK Antibody is available in the following size(s): 0.1 mg.

Is TANK Antibody in stock?

TANK Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

TANK Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

TRAF family member associated NFKB activator

Gene Aliases

ITRAF; I-TRAF; TRAF family member-associated NF-kappa-B activator; TRAF2; TRAF-interacting protein.

Gene ID

10010

Accession Number

https://www.ncbi.nlm.nih.gov/protein/NP_004171

Reactivity

Human|Mouse

Immunogen

TANK antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TANK. The immunogen is located within amino acids 60 - 110 of TANK.

Target

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989) . Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989) . Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989) . May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Immunocytochemistry|Western blot

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Homology

Human

Format

Liquid. TANK Antibody is supplied in PBS containing 0.02% sodium azide.

Reconstitution

TANK antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.