SARM Antibody
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Product Specifications
CAS Number
9007-83-4
Gene Name
Sterile alpha and TIR motif containing 1
Gene Aliases
HSARM1; HsTIR; MyD88-5; NAD (+) hydrolase SARM1; NADase SARM1; NADP (+) hydrolase SARM1; SAM domain-containing protein 2; SAMD2; SARM; sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif-containing protein 1; sterile alpha motif domain-containing protein 2; tir-1 homolog.
Gene ID
23098
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_055892
Reactivity
Human|Mouse|Porcine
Immunogen
SARM antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human SARM. The immunogen is located within amino acids 640 - 690 of SARM.
Target
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse
Format
Liquid. SARM Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
2°C to 8°C
Molecular Weight
Predicted: 80 kDa Observed: 85 kDa
Notes
Formerly GWB-B44CBF
NCBI Gene Symbol
SARM1
Host or Source
Rabbit
Protein Name
Sterile alpha and TIR motif-containing protein 1|sterile alpha and TIR motif-containing protein 1 precursor [Homo sapiens]
Gene Name URL
SARM1
Curated Selection
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