DIABLO Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Diablo, IAP-binding mitochondrial protein

Gene Aliases

0610041G12Rik;1700006L01Rik; AU040403; diablo homolog, mitochondrial; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase; Sm; Smac.

Gene ID

66593

Accession Number

NP_001265231.1NP_001265232.1NP_001265233.1NP_001265271.1NP_063940.1NP_620308.1

Reactivity

Human|Mouse|Rat

Immunogen

Anti-Smac antibody (2411) was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of murine Smac. The immunogen is located within the last 50 amino acids of Smac.

Target

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) . Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Homology

Human; Mouse; Rat

Format

Liquid. Smac Antibody is supplied in PBS containing 0.02% sodium azide.

Reconstitution

Smac antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.