TNFRSF10A Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
TNF receptor superfamily member 10a
Gene Aliases
APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAILR1; TRAILR-1; TRAIL-R1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a.
Gene ID
8797
Accession Number
https://www.ncbi.nlm.nih.gov/protein/AAC51226
Reactivity
Human|Mouse|Rat
Immunogen
Anti-DR4 antibody (1139) was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of human DR4. The immunogen is located within the last 50 amino acids of DR4.
Target
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518) . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human
Format
Liquid. DR4 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
2°C to 8°C
Molecular Weight
Predicted: 50kD Observed: 55kD (Post-modification: 1 N-linked glycosylation)
Notes
Formerly GWB-A9753D
NCBI Gene Symbol
TNFRSF10A
Host or Source
Rabbit
Protein Name
Cytotoxic ligand TRAIL receptor [Homo sapiens]|Tumor necrosis factor receptor superfamily member 10A
Gene Name URL
TNFRSF10A
Nucleotide Accession Number
NM_003844.3
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