DDR1-IN-4

DDR1-IN-4 (Compound 2.45) is a selective and potent Discoidin Domain Receptor 1 (DDR1) autophosphorylation inhibitor, with IC50 values of 29 nM and 1.9 μM for DDR1 and DDR2, respectively[1].

Product Specifications

CAS Number

[2125676-13-1]

Product Name Alternative

Mitoglitazone; CAY10415

UNSPSC

12352005

Target

Discoidin Domain Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ddr1-in-4.html

Purity

98.19

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCC(F)(F)F)CN1C(C2(CCN(C(C3=CC=C(NN=C4)C4=N3)=O)CC2)C5=C1C=CC=C5Br)=O

Molecular Formula

C23H20BrF3N6O3

Molecular Weight

565.34

References & Citations

[1]Hans Richter, et al. DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome. ACS Chem Biol. 2019 Jan 18;14 (1) :37-49.