DOTA-NHS-ester (TFA)
DOTA-NHS-ester (TFA) is used as a linker for affibody molecules, and it can be employed in small animal positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT scanning. DOTA-NHS-ester can be used to label radiotracers or imaging probes for tumor detection[1].
Product Specifications
UNSPSC
12352005
Target
ADC Linker; Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dota-nhs-ester-tfa.html
Purity
95.00
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.O=C(ON1C(CCC1=O)=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2
Molecular Formula
C22H32F3N5O12
Molecular Weight
615.51
References & Citations
[1]Hoppmann S, et al. Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting. Bioconjug Chem. 2011 Mar 16;22 (3) :413-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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