What is the catalog number for SOCS3 Antibody?

The catalog number for SOCS3 Antibody is OALA03243-50UG.

What sizes are available for SOCS3 Antibody?

SOCS3 Antibody is available in the following size(s): 50 µg.

Is SOCS3 Antibody in stock?

SOCS3 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

SOCS3 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Aliases

SOCS3, Cish3, Cytokine-induced SH2 protein 3, CIS-3, CIS3, SSI-3, STAT-induced STAT inhibitor 3, SSI3, ATOD4, SOCS-3

Gene ID

9021

Accession Number

NP_003946.3

Reactivity

Human

Immunogen

Full - length SOCS3 protein.

Clonality

Monoclonal

Clone

SO1

Conjugation

Unconjugated

Type

Monoclonal Antibody

Applications

ELISA, IHC, IHC-P, WB

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Format

Liquid

Buffer

PBS, 0.09% Sodium Azide

Reconstitution

Store at 4C or at -20C. Store undiluted. Avoid freeze/thaw cycles.

Fragment

IgG2b

Specificity

Recognizes suppressor of cytokine signaling 3 (SOCS3), a 30kD member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways. SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn's Disease. SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies.