FZD9 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Aliases

FZD9, CD349, Frizzled homolog 9, Fz-9, Frizzled family receptor 9, Frizzled-9, Frizzled 9, Fz9, HFz9, CD349 antigen, Frizzled homolog fzd3, FzE6

Gene ID

8326

Accession Number

NP_003499.1

Reactivity

Human

Immunogen

Synthetic 17 amino acid peptide from 3rd extracellular domain of human FZD9 / Frizzled 9. Percent identity with other species by BLAST analysis: Human, Gibbon (100%) ; Mouse, Rat, Dog, Panda (94%) ; Bat, Bovine, Hamster, Opossum (88%) ; Rabbit (82%) .

Target

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling.

Clonality

Polyclonal

Epitope

Extracellular Domain

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

ELISA, IHC, IHC-P

Purification

Immunoaffinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Homology

Percent identity with other species by BLAST analysis: Gibbon (100%) ; Panda (94%) ; Opossum (88%) ; Rabbit (82%)

Format

Liquid.// PBS, 0.1% Sodium Azide

Buffer

PBS, 0.1% Sodium Azide

Reconstitution

Aliquot and store undiluted at -20C or below for up to 1 year. Can be stored undiluted at 4C for up to 1 month. Avoid freeze-thaw cycles.

Notes

Formerly GWB-2FBC0D

Specificity

Human FZD9 / Frizzled 9. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD10 (47%) .

Formulation

NCBI Gene Symbol

FZD9

Host or Source

Rabbit

Gene Name URL

FZD9

Nucleotide Accession Number

NM_003508

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