IL10 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Interleukin 10
Gene Aliases
CSIF, TGIF, GVHDS, IL-10, IL10A
Gene ID
3586
Accession Number
NP_000563.1
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein encompassing a sequence within the center region of human IL10. The exact sequence is proprietary.
Target
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Clonality
Monoclonal
Clone
GT5111
Type
Monoclonal Antibody
Applications
WB, IHC-FFPE
Purification
Affinity purified by Protein G.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1.19 mg/ml
Homology
Cat (86%), Rabbit (83%), Sheep (85%), Rhesus Monkey (93%), Chimpanzee (98%), Bovine (81%), Guinea Pig (88%)
Format
Liquid// PBS
Reconstitution
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Molecular Weight
21 kDa
Fragment
IgG1
NCBI Gene Symbol
IL10
Host or Source
Mouse
Protein Name
Interleukin-10
Gene Name URL
IL10
Nucleotide Accession Number
NM_000572.2
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