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Padnarsertib

Product Specifications

Product Name Alternative

KPT-9274

UNSPSC Description

Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC50s of [1][2][3].

Target Antigen

NAMPT; PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PAK4-IN-1.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1C2=C(OC(CNC(/C=C/C3=CN=C(N)C=C3)=O)=C4)C4=CC(C5=CC=C(C(N6CCC(F)(F)CC6)=O)C=C5)=C2

Molecular Weight

610.63

References & Citations

[1]WO2015003166A1|[2]Abu Aboud O, et al. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 Sep;15(9):2119-29.|[3]Abu Aboud O, et al. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15(9):2119-29.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-12793/Padnarsertib-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12793/Padnarsertib-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

1643913-93-2

Available Sizes

Curated Selection

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