Padnarsertib
Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC50s of [1][2][3].
Product Specifications
CAS Number
[1643913-93-2]
Product Name Alternative
KPT-9274
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAMPT; PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PAK4-IN-1.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C=C1)=CC=C1C2=C(OC(CNC(/C=C/C3=CN=C(N)C=C3)=O)=C4)C4=CC(C5=CC=C(C(N6CCC(F)(F)CC6)=O)C=C5)=C2
Molecular Formula
C35H29F3N4O3
Molecular Weight
610.63
Precautions
H302, H315, H319, H335
References & Citations
[1]WO2015003166A1|[2]Abu Aboud O, et al. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 Sep;15 (9) :2119-29.|[3]Abu Aboud O, et al. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15 (9) :2119-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PAK4
Available Sizes
Curated Selection
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