TNFRSF10A Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
TNF receptor superfamily member 10a
Gene Aliases
APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAILR1; TRAILR-1; TRAIL-R1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a.
Gene ID
8797
Accession Number
NP_003835.3
Reactivity
Human
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Target
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518) . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Clonality
Monoclonal
Clone
DR-4-02
Conjugation
FITC
Type
Monoclonal Antibody
Applications
Flow cytometry
Purification
Purified by size-exclusion chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.1 mg/ml
Format
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
NCBI Gene Symbol
TNFRSF10A
Host or Source
Mouse
Protein Name
Tumor necrosis factor receptor superfamily member 10A
Gene Name URL
TNFRSF10A
Nucleotide Accession Number
NM_003844.3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1145970-01 0.02 mg (E-Coli)
Recombinant Klebsiella pneumoniae subsp. pneumoniae Imidazolonepropionase (hutI)
Ask
View Details MBS1145970-02 0.02 mg (Yeast)
Recombinant Klebsiella pneumoniae subsp. pneumoniae Imidazolonepropionase (hutI)
Ask
View Details 
MBS1145970-03 0.1 mg (E-Coli)
Recombinant Klebsiella pneumoniae subsp. pneumoniae Imidazolonepropionase (hutI)
Ask
View Details 
MBS1145970-04 0.1 mg (Yeast)
Recombinant Klebsiella pneumoniae subsp. pneumoniae Imidazolonepropionase (hutI)
Ask
View Details MBS1145970-05 0.02 mg (Baculovirus)
Recombinant Klebsiella pneumoniae subsp. pneumoniae Imidazolonepropionase (hutI)
Ask
View Details MBS1145970-06 0.02 mg (Mammalian-Cell)
Recombinant Klebsiella pneumoniae subsp. pneumoniae Imidazolonepropionase (hutI)
Ask
View Details