LAT2 Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Linker for activation of T cells family, member 2

Gene Aliases

AW125574; LAB; linker for activation of B-cells; linker for activation of T-cells family member 2; membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; NTAL; Wbsc; Wbscr; Wbscr15; Wbscr5; williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosome region 5 homolog; WSCR5.

Gene ID

56743

Accession Number

NP_054865.2NP_115852.1NP_115853.2

Reactivity

Human|Mouse

Immunogen

Recombinant cytoplasmic domain (aa 91-243) of human NTAL.

Target

Involved in FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor) -mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I) -mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

Clonality

Monoclonal

Clone

NAP-07

Type

Monoclonal Antibody

Applications

Flow cytometry|Immunocytochemistry|Immunoprecipitation|Western blot

Purification

Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Format

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Buffer

Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Reconstitution

2°C to 8°C

Fragment

IgG1

Specificity

The antibody NAP-07 reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells.