TFRC Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Transferrin receptor
Gene Aliases
CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR.
Gene ID
7037
Accession Number
NP_001121620.1NP_003225.2
Reactivity
Human
Immunogen
KG1 human acute myelogenous leukaemia cell line
Target
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240) .
Clonality
Monoclonal
Clone
MEM-189
Type
Monoclonal Antibody
Applications
Flow cytometry|Immunoprecipitation|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Buffer
Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
HLDA VI; WS Code NL N-L025//
NCBI Gene Symbol
TFRC
Host or Source
Mouse
Protein Name
Transferrin receptor protein 1
Gene Name URL
TFRC
Nucleotide Accession Number
NM_001128148.1NM_003234.2
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