CD6 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
CD6 molecule
Gene Aliases
CD6 antigen; T12; T-cell differentiation antigen CD6; TP120.
Gene ID
923
Accession Number
NP_001241679.1NP_001241680.1NP_006716.3XP_006718801.1XP_006718804.1
Reactivity
Human
Immunogen
Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) .
Target
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089) . Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089) . Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752) . Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806) . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777) . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777) . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777) .
Clonality
Monoclonal
Clone
MEM-98
Type
Monoclonal Antibody
Applications
Flow cytometry|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
The MEM-98 antibody reacts with CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
NCBI Gene Symbol
CD6
Host or Source
Mouse
Protein Name
T-cell differentiation antigen CD6
Gene Name URL
CD6
Nucleotide Accession Number
NM_001254750.1NM_001254751.1NM_006725.4XM_006718738.1XM_006718741.1
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