CD4 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
CD4 molecule
Gene Aliases
CD4 antigen (p55) ; CD4 receptor; CD4mut; IMD79; OKT4D; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4.
Gene ID
920
Accession Number
NP_000607.1
Reactivity
Human
Immunogen
2 N-terminal domains of human CD4 fused to human IgG1 Fc
Target
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Clonality
Monoclonal
Clone
MEM-241
Conjugation
Biotin
Type
Monoclonal Antibody
Applications
Flow cytometry|Western blot
Purification
Purified by size-exclusion chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
HCDM (former HLDA VIII) Meeting, May 2006, Québec, Canada; WS Code M241// HCDM (former HLDA VIII) Meeting, May 2006, Québec, Canada; WS Code M241//
NCBI Gene Symbol
CD4
Host or Source
Mouse
Protein Name
T-cell surface glycoprotein CD4
Gene Name URL
CD4
Nucleotide Accession Number
NM_000616.4
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS726014-01 48 Well
Guinea pig Intrinsic factor antibody ELISA Kit
Sign In for Pricing
View Details MBS726014-02 96 Well
Guinea pig Intrinsic factor antibody ELISA Kit
Sign In for Pricing
View Details MBS726014-03 5x 96 Well
Guinea pig Intrinsic factor antibody ELISA Kit
Sign In for Pricing
View Details MBS726014-04 10x 96 Well
Guinea pig Intrinsic factor antibody ELISA Kit
Sign In for Pricing
View Details