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CD300A Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

CD300a molecule

Gene Aliases

CD300 antigen-like family member A; CD300a antigen; CLM-8; CMRF35H; CMRF35-H; CMRF-35H; CMRF35H leukocyte immunoglobulin-like receptor; CMRF35H9; CMRF35-H9; CMRF-35-H9; CMRF35-like molecule 8; IGSF12; immunoglobulin superfamily member 12; inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; leukocyte membrane antigen; NK inhibitory receptor.

Gene ID

11314

Accession Number

NP_001243770.1NP_009192.2

Reactivity

Human

Immunogen

HPB human acute lymphoid leukemia cell line

Target

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027) . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923) .

Clonality

Monoclonal

Clone

MEM-260

Type

Monoclonal Antibody

Applications

Flow cytometry|Western blot

Purification

Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 mg/ml

Format

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Buffer

Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Reconstitution

2°C to 8°C

Fragment

IgG1

Specificity

The antibody MEM-260 reacts with CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.

NCBI Gene Symbol

CD300A

Host or Source

Mouse

Protein Name

CMRF35-like molecule 8

Gene Name URL

CD300A

Nucleotide Accession Number

NM_001256841.1NM_007261.3

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