LAMP2 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Lysosomal associated membrane protein 2
Gene Aliases
CD107 antigen-like family member B; CD107b; DND; LAMP-2; LAMPB; LGP110; LGP-96; lysosome-associated membrane glycoprotein 2.
Gene ID
3920
Accession Number
NP_001116078.1NP_002285.1NP_054701.1
Reactivity
Human
Immunogen
Human PBMC
Target
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032) . Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125) . Plays a role in lysosomal protein degradation in response to starvation (By similarity) . Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032) . Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032) . Required for normal degradation of the contents of autophagosomes (PubMed:27628032) . Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820) . Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820) .
Clonality
Monoclonal
Clone
H4B4
Type
Monoclonal Antibody
Applications
Flow cytometry|Immunocytochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4
Buffer
Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
HLDA V.; WS Code P007//
NCBI Gene Symbol
LAMP2
Host or Source
Mouse
Protein Name
Lysosome-associated membrane glycoprotein 2
Gene Name URL
LAMP2
Nucleotide Accession Number
NM_001122606.1NM_002294.2NM_013995.2
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