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Anti-APRIL (Sacha-2) Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Adiponectin, C1Q and collagen domain containing|TNF superfamily member 13

Gene Aliases

30 kDa adipocyte complement-related protein; a proliferation-inducing ligand; ACDC; ACRP30; adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; adiponectin; adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADIPQTL1; ADPN; APM1; APM-1; APRIL; CD256; GBP28; Gelatin-binding protein; gelatin-binding protein 28; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNLG7B; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; UNQ383/PRO715; ZTNF2.

Gene ID

8741|9370

Reactivity

Human|Mouse

Immunogen

Recombinant human APRIL (aa 105-250) fused to human ACRP30headless (aa 16-108) (Prod. No. ALX-522-035) .

Target

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.|Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Clonality

Monoclonal

Clone

Sacha-2

Type

Monoclonal Antibody

Source

Purified from concentrated hybridoma tissue culture supernatant.

Applications

Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1mg/ml

Reconstitution

Long Term Storage : //+4C Handling : //Do not freeze/thaw. Stable for at least 6 months after receipt when stored at +4C undiluted.Handling : //Do not freeze/thaw. Stable for at least 6 months after receipt when stored at +4C undiluted.

Fragment

IgG2a

Specificity

Recognizes human and mouse APRIL.

NCBI Gene Symbol

ADIPOQ|TNFSF13

Host or Source

Rat

Protein Name

Adiponectin|Tumor necrosis factor ligand superfamily member 13

Gene Name URL

ADIPOQ|TNFSF13

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