Anti-APRIL (Sacha-2) Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Adiponectin, C1Q and collagen domain containing|TNF superfamily member 13
Gene Aliases
30 kDa adipocyte complement-related protein; a proliferation-inducing ligand; ACDC; ACRP30; adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; adiponectin; adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADIPQTL1; ADPN; APM1; APM-1; APRIL; CD256; GBP28; Gelatin-binding protein; gelatin-binding protein 28; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNLG7B; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand 7B; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; UNQ383/PRO715; ZTNF2.
Gene ID
8741|9370
Reactivity
Human|Mouse
Immunogen
Recombinant human APRIL (aa 105-250) fused to human ACRP30headless (aa 16-108) (Prod. No. ALX-522-035) .
Target
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.|Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Clonality
Monoclonal
Clone
Sacha-2
Type
Monoclonal Antibody
Source
Purified from concentrated hybridoma tissue culture supernatant.
Applications
Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1mg/ml
Reconstitution
Long Term Storage : //+4C
Handling : //Do not freeze/thaw.
Stable for at least 6 months after receipt when stored at +4C undiluted.Handling : //Do not freeze/thaw.
Stable for at least 6 months after receipt when stored at +4C undiluted.
Fragment
IgG2a
Specificity
Recognizes human and mouse APRIL.
NCBI Gene Symbol
ADIPOQ|TNFSF13
Host or Source
Rat
Protein Name
Adiponectin|Tumor necrosis factor ligand superfamily member 13
Gene Name URL
ADIPOQ|TNFSF13
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