THP-PEG6-OH
THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
Product Specifications
CAS Number
[42607-87-4]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thp-peg6-oh.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
OCCOCCOCCOCCOCCOCCOC1CCCCO1
Molecular Formula
C17H34O8
Molecular Weight
366.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.|[2]Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RR202354L3V 200 µL
Map3k7cl (NM_001013979) Rat Tagged ORF Clone Lentiviral Particle
Ask
View Details GTR15284834 1 Vial
Lentiviral mouse Slc4a1 shRNA (UAS) - Lentiviral mouse Slc4a1 shRNA (UAS, iRFP) (25)
Ask
View Details 
MBS6290643-01 0.2 mL
D19L4, NT (DPY19L4, Protein dpy-19 homolog 4, Dpy-19-like protein 4) (Azide free) (HRP)
Ask
View Details MBS6290643-02 5x 0.2 mL
D19L4, NT (DPY19L4, Protein dpy-19 homolog 4, Dpy-19-like protein 4) (Azide free) (HRP)
Ask
View Details MBS7101076 Inquire
Recombinant Pan troglodytes Cytochrome c oxidase subunit 3 (MT-CO3), partial
Ask
View Details