THP-PEG6-OH

THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

CAS Number

[42607-87-4]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thp-peg6-oh.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

OCCOCCOCCOCCOCCOCCOC1CCCCO1

Molecular Formula

C17H34O8

Molecular Weight

366.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.|[2]Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1.