HSPA5 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Heat shock protein family A (Hsp70) member 5
Gene Aliases
78 kDa glucose-regulated protein; binding-immunoglobulin protein; BIP; endoplasmic reticulum chaperone BiP; GRP 78; GRP78; GRP-78; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kDa protein 5 (glucose-regulated protein) ; heat shock protein 5; heat shock protein 70 family protein 5; heat shock protein family A member 5; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; steroidogenesis-activator polypeptide.
Gene ID
25617
Accession Number
NP_005338.1
Reactivity
Bovine|Fungus|Hamster|Monkey|Mouse|Rabbit|Rat|Xenopus
Immunogen
Synthetic peptide corresponding to the sequence near the C-terminus of rat Grp78 (BiP) . The sequence is completely conserved in mouse and hamster.
Target
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity) . Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity) . Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) . In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Western blot
Purification
Protein A affinity purified.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid// PBS containing 50% glycerol and 0.09% sodium azide.
Reconstitution
Long Term Storage :// -20°C. Avoid freeze/thaw cycles.
Specificity
Detects a band of ~78kDa by Western blot.
NCBI Gene Symbol
Hspa5
Host or Source
Rabbit
Protein Name
Endoplasmic reticulum chaperone BiP
Gene Name URL
Hspa5
Nucleotide Accession Number
NM_005347.4
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