HSPA8 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Heat shock cognate 71 kDa protein
Gene Aliases
LAP1, HSC54, HSC70, HSC71, HSP71, HSP73, LAP-1, NIP71, HEL-33, HSPA10, HEL-S-72p
Gene ID
3312
Accession Number
NP_006588.1NP_694881.1
Reactivity
Human, Mouse, Beluga, Bovine, Dog, Chicken, Fish
Immunogen
Native human Hsp70/Hsc70.
Target
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78) . Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
Clonality
Monoclonal
Clone
N27F34
Type
Monoclonal Antibody
Applications
FC
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Reconstitution
Long Term Storage : //-20C
Fragment
IgG1
Specificity
Recognizes human, mouse, beluga, bovine, dog, chicken and fish HSC70 (HSP70) . Detects bands of ~72kDa (HSP70), ~73kDa (HSC70) by Western blot.
NCBI Gene Symbol
HSPA8
Host or Source
Mouse
Protein Name
Heat shock cognate 71 kDa protein
Gene Name URL
HSPA8
Nucleotide Accession Number
NM_006597.5NM_153201.3
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