Anti-PDK1 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Pyruvate dehydrogenase kinase 1
Gene Aliases
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; Pyruvate dehydrogenase kinase isoform 1; pyruvate dehydrogenase kinase, isoenzyme 1.
Gene ID
5163
Reactivity
Dog|Human|Monkey|Mouse|Porcine|Rabbit|Rat
Immunogen
Synthetic peptide corresponding to a portion of human PDK1 (Pyruvate dehydrogenase kinase-1) .
Target
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Western blot
Purification
Protein A affinity purified.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Format
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Reconstitution
Long Term Storage : //-20C
Specificity
Recognizes human, mouse, rat, dog, monkey, pig and rabbit PDK1 (Pyruvate dehydrogenase kinase) . Detects a band of ~48kDa by Western blot.
NCBI Gene Symbol
PDK1
Host or Source
Rabbit
Protein Name
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial
Gene Name URL
PDK1
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