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IL-1beta Antibody - PE Conjugated

Product Specifications

CAS Number

9007-83-4

Gene Name

Interleukin 1 beta

Gene Aliases

IL-1, IL1F2, IL1beta, IL1-BETA

Gene ID

3553

Accession Number

NP_000567.1

Reactivity

Human

Target

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clonality

Monoclonal

Clone

B-A15

Conjugation

PE: Phycoerythrin

Type

Monoclonal Antibody

Applications

FC

Purification

Ion exchange chromatography

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

100 tests/1mL

Format

Lyophilized

Buffer

Phosphate-buffered saline with 1 % BSA and 0.1 % sodium azide

Reconstitution

Reconstitute with 1mL of deionized water. It is recommended to establish the optimal dilution according to the system being used. Use 10 uL of antibody to label 5.105 cells. Stable at +2-8C for 12 months. For longer storage, freeze aliquots

Molecular Weight

31 kDa

Fragment

Mouse IgG1

Specificity

Recognises natural and recombinant human IL-1b

NCBI Gene Symbol

IL-1beta

Host or Source

Mouse

Protein Name

Interleukin-1 beta

Gene Name URL

IL-1beta

Nucleotide Accession Number

NM_000576.2

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