IL-1beta Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Interleukin 1 beta
Gene Aliases
IL-1, IL1F2, IL1beta, IL1-BETA
Gene ID
3553
Accession Number
NP_000567.1
Reactivity
Human
Target
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Clonality
Monoclonal
Clone
B-A15
Type
Monoclonal Antibody
Applications
BL, FC
Purification
Ion exchange chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 ug/uL
Bioactivity
Blocks IL-1b induced proliferation on D10S murine cell line
Format
Lyophilized
Buffer
Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free
Reconstitution
Store at +2-8C for 12 months. For longer storage, freeze aliquots
Molecular Weight
31 kDa
Fragment
Mouse IgG1
Specificity
Recognises both natural (pro and mature) and recombinant human IL-1b
NCBI Gene Symbol
IL-1beta
Host or Source
Mouse
Protein Name
Interleukin-1 beta
Gene Name URL
IL-1beta
Nucleotide Accession Number
NM_000576.2
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