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IL-17A Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

Interleukin 17A

Gene Aliases

IL17, CTLA8, IL-17, CTLA-8, IL-17A

Gene ID

3605

Accession Number

NP_002181.1

Reactivity

Human

Target

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Clonality

Monoclonal

Clone

B-B51

Type

Monoclonal Antibody

Applications

NT

Purification

Ion exchange chromatography

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1 ug/uL

Bioactivity

Neutralises the bioactivity of IL-17A on keratinocytes cell line HaCaT

Format

Lyophilized

Buffer

Phosphate-buffered saline. Sterile-filtered through 0.22 um and treated to remove endotoxins. Carrier and preservative free

Reconstitution

Stable at +2-8C for 12 months. For longer storage, freeze aliquots

Molecular Weight

18 kDa

Fragment

Mouse IgG2b

Specificity

Recognizes both recombinant and natural human IL-17A

NCBI Gene Symbol

IL-17A

Host or Source

Mouse

Protein Name

Interleukin-17A

Gene Name URL

IL-17A

Nucleotide Accession Number

NM_002190.2

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